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KMID : 1007520100190041119
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Food Science and Biotechnology
2010 Volume.19 No. 4 p.1119 ~ p.1122
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Inhibitory Effect of Ginsenosides from Ginseng Leaves and Flowers on the LPS-stimulated IL-12 Production in Bone Marrow-derived Dendritic Cells
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Nguyen Huu Tung
Song Seok-Bean
Song Gyu-Yong
Kim Jeong-Ah
Koo Jung-Eun
Kang Hee-Kyoung
Koh Young-Sang
Kim Young-Ho
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Abstract
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Ginseng leaves and flowers have been known to be rich in various ginsenosides. The aim of present study is to screen the effect of 34 ginsenosides from ginseng leaves and flowers on interlukin (IL)-12 production in bone marrow-derived dendritic cells induced by lipopolysaccharide (LPS). Noticeably, floralginsenoside Kc (5), floralginsenoside J (26), and ginsenoside I (33) exhibited particularly inhibitory effect on LPS-induced IL-12 production with IC50 values of 16.3, 25.8, and 6.7 μM, respectively. In addition, floralginsenoside Kc (5) suppressed significantly LPS-stimulated IL-6 and tumor necrosis factor-α (TNF-α) production. These results warrant further studies concerning potential of saponin extracts of Panax ginseng leaves and flowers for medicinal foods.
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KEYWORD
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interleukin-12, Panax ginseng, ginsenoside, bone marrow-derived dendritic cell
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